研究・業績

2012年

1. Kawamura Y, Takasaki S, Mizokami MUsing Decision Tree Learning to Predict the Res ponsiveness of Hepatitis C Patients to Drug Treatment.   FEBS Open Bio 2: 98-102 2012.01

2. Nishida N, Mawatari Y, Sageshima M, Tokunaga K.  Highly Parallel and Short-Acting Amplification with Locus-Specific Primers to Detect Single Nucleotide Polymorphisms by the Digitag2 Assay.   PLoS One 7 (1): e29967 2012.01.19

3. Nakano T, Lau GM, Sugiyama M, Mizokami MAn Updated Analysis of Hepatitis C Virus Genotypes and Subtypes Based on the Complete Coding Region.   Liver Int 32 (2): 339-45 2012.02

4. Ragheb M, Elkady A, Tanaka Y, Murakami S, Attia FM, Hassan AA, Hassan MF, Shedid MM, Abdel Reheem HB, Khan A, Mizokami MMultiple Int ra-Familial Transmission Patterns of Hepatitis B Virus Genotype D in North-Eastern Egypt.   J Med Virol 84 (4): 587-95 2012.04

5. Kani S, Tanaka Y, Matsuura K, Watanabe T, Yatsuhashi H, Orito E, Inose K, Motojuku N, Wakimoto Y, Mizokami MDevelopment of New Il28b Genotyping Method Using Invader Plus Assay.   Microbiol Immunol 56 (5): 318-23 2012.05

6. Nishida N, Sawai H, Matsuura K, Sugiyama M, Ahn SH, Park JY, Hige S, Kang JH, Suzuki K, Kurosaki M, Asahina Y, Mochida S, Watanabe M, Tanaka E, Honda M, Kaneko S, Orito E, Itoh Y, Mita E, Tamori A, Murawaki Y, Hiasa Y, Sakaida I, Korenaga M, Hino K, Ide T, Kawashima M, Mawatari Y, Sageshima M, Ogasawara Y, Koike A, Izumi N, Han KH, Tanaka Y, Tokunaga K, Mizokami MGenome-Wide Association Study Confirming Association of Hla-Dp with Protection against Chronic Hepatitis B and Viral Clearance in Japanese and Korean.   PLoS One 7 (6): e39175 2012.06.28

7. Nomura H, Miyagi Y, Tanimoto H, Yamashita N, Ito K, Masaki N, Mizokami MIncrease in Platelet Count Based on Inosine Triphosphatase Genotype During Int erferon Beta Plus Ribavirin Combination Therapy.   J Gastroenterol Hepatol 27 (9): 1461-6 2012.09

8. Ito K, Kuno A, Ikehara Y, Sugiyama M, Saito H, Aoki Y, Matsui T, Imamura M, Korenaga M, Murata K, Masaki N, Tanaka Y, Hige S, Izumi N, Kurosaki M, Nishiguchi S, Sakamoto M, Kage M, Narimatsu H, Mizokami MLect-Hepa, a Glyco-Marker Derived from Multiple Lectins, as a Predictor of Liver Fibrosis in Chronic Hepatitis C Patients.   Hepatology 56 (4): 1448-56 2012.10

9. Saito H, Ito K, Sugiyama M, Matsui T, Aoki Y, Imamura M, Murata K, Masaki N, Nomura H, Adachi H, Hige S, Enomoto N, Sakamoto N, Kurosaki M, Mizokami M, Watanabe S.  Factors Res ponsible for the Discrepancy between Il28b Polymorphism Prediction and the Viral Res ponse to Peginterferon Plus Ribavirin Therapy in Japanese Chronic Hepatitis C Patients.   Hepatol Res 42 (10): 958-965 2012.10

10. Sugiyama M, Kimura T, Naito S, Mukaide M, Shinauchi T, Ueno M, Ito K, Murata K, Mizokami MDevelopment of Specific and Quantitative Real-Time Detection Pcr and Immunoassays for Lambda3-Int erferon.   Hepatol Res 42 (11): 1089-99 2012.11

共著論文

1. Murayama A, Kato T, Akazawa D, Sugiyama N, Date T, Masaki T, Nakamoto S, Tanaka Y, Mizokami M, Yokosuka O, Nomoto A, Wakita T.  Production of Infectious Chimeric Hepatitis C Virus Genotype 2b Harboring Minimal Regions of Jfh-1.   J Virol 86 (4): 2143-52 2012.02

2. Raghwani J, Thomas XV, Koekkoek SM, Schinkel J, Molenkamp R, van de Laar TJ, Takebe Y, Tanaka Y, Mizokami M, Rambaut A, Pybus OG.  Origin and Evolution of the Unique Hepatitis C Virus Circulating Recombinant Form 2k/1b.   J Virol 86 (4): 2212-20 2012.02

3. Shimogiri T, Nishida N, Kudo M, Niwa K, Nishibori M, Kinoshita K, Okamoto S, Maeda Y, Tokunaga K, Yasue H.  Genet ic Relationships between Japanese Native and Commercial Breeds Using 70 Chicken Autosomal Snp Genotypes by the Digitag2 Assay.   Anim Genet 43 (1): 98-103 2012.02

4. Narahara Y, Kanazawa H, Sakamoto C, Maruyama H, Yokosuka O, Mochida S, Uemura M, Fukui H, Sumino Y, Matsuzaki Y, Masaki N, Kokubu S, Okita K.  The Efficacy and Safety of Terlipressin and Albumin in Patients with Type 1 Hepatorenal Syndrome: A Multicenter, Open-Label, Explorative Study.   J Gastroenterol 47 (3): 313-20 2012.03

5. Hirata M, Kugimiya F, Fukai A, Saito T, Yano F, Ikeda T, Mabuchi A, Sapkota BR, Akune T, Nishida N, Yoshimura N, Nakagawa T, Tokunaga K, Nakamura K, Chung UI, Kawaguchi H.  C/Ebpbeta and Runx2 Cooperate to Degrade Cartilage with Mmp-13 as the Target and Hif-2alpha as the Inducer in Chondrocytes.   Hum Mol Genet 21 (5): 1111-23 2012.03.1

6. Okada Y, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Kawaguchi T, Stahl EA, Kurreeman FA, Nishida N, Ohmiya H, Myouzen K, Takahashi M, Sawada T, Nishioka Y, Yukioka M, Matsubara T, Wakitani S, Teshima R, Tohma S, Takasugi K, Shimada K, Murasawa A, Honjo S, Matsuo K, Tanaka H, Tajima K, Suzuki T, Iwamoto T, Kawamura Y, Tanii H, Okazaki Y, Sasaki T, Gregersen PK, Padyukov L, Worthington J, Siminovitch KA, Lathrop M, Taniguchi A, Takahashi A, Tokunaga K, Kubo M, Nakamura Y, Kamatani N, Mimori T, Plenge RM, Yamanaka H, Momohara S, Yamada R, Matsuda F, Yamamoto K.  Meta-Analysis Identifies Nine New Loci Associated with Rheumatoid Arthritis in the Japanese Population.   Nat Genet 44 (5): 511-6 2012.03.27

7. Date T, Morikawa K, Tanaka Y, Tanaka-Kaneko K, Sata T, Mizokami M, Wakita T.  Replication and Infectivity of a Novel Genotype 1b Hepatitis C Virus Clone.   Microbiol Immunol 56 (5): 308-17 2012.05

8. Tamada Y, Yatsuhashi H, Masaki N, Nakamuta M, Mita E, Komatsu T, Watanabe Y, Muro T, Shimada M, Hijioka T, Satoh T, Mano Y, Komeda T, Takahashi M, Kohno H, Ota H, Hayashi S, Miyakawa Y, Abiru S, Ishibashi H.  Hepatitis B Virus Strains of Subgenotype A2 with an Identical Sequence Spreading Rapidly from the Capital Region to All over Japan in Patients with Acute Hepatitis B.   Gut 61 (5): 765-73 2012.05

9. Sawada N, Inoue M, Iwasaki M, Sasazuki S, Shimazu T, Yamaji T, Takachi R, Tanaka Y, Mizokami M, Tsugane S.  Consumption of N-3 Fatty Acids and Fish Reduces Risk of Hepatocellular Carcinoma.   Gastroenterol ogy 142 (7): 1468-75 2012.06

10. Zhou B, Wang Z, Yang J, Sun J, Li H, Tanaka Y, Mizokami M, Hou J.  Novel Evidence of Hbv Recombination in Family Cluster Infections in Western China.   PLoS One 7 (6): e38241 2012.06.8

11. Sawai H, Nishida N, Mbarek H, Matsuda K, Mawatari Y, Yamaoka M, Hige S, Kang JH, Abe K, Mochida S, Watanabe M, Kurosaki M, Asahina Y, Izumi N, Honda M, Kaneko S, Tanaka E, Matsuura K, Itoh Y, Mita E, Korenaga M, Hino K, Murawaki Y, Hiasa Y, Ide T, Ito K, Sugiyama M, Ahn SH, Han KH, Park JY, Yuen MF, Nakamura Y, Tanaka Y, Mizokami M, Tokunaga K.  No Association for Chinese Hbv-Related Hepatocellular Carcinoma Susceptibility Snp in Other East Asian Populations.   BMC Med Genet 13 (1): 47 2012.06.19

12. Zeissig S, Murata K, Sweet L, Publicover J, Hu Z, Kaser A, Bosse E, Iqbal J, Hussain MM, Balschun K, Rocken C, Arlt A, Gunther R, Hampe J, Schreiber S, Baron JL, Moody DB, Liang TJ, Blumberg RS.  Hepatitis B Virus-Induced Lipid Alterations Contribute to Natural Killer T Cell-Dependent Protective Immunity.   Nat Med 18 (7): 1060-8 2012.07

13. Michikawa T, Inoue M, Sawada N, Iwasaki M, Tanaka Y, Shimazu T, Sasazuki S, Yamaji T, Mizokami M, Tsugane S.  Development of a Prediction Model for 10-Year Risk of Hepatocellular Carcinoma in Middle-Aged Japanese: The Japan Public Health Center-Based Prospective Study Cohort Ii.   Prev Med 55 (2): 137-43 2012.08

14. Date T, Kato T, Kato J, Takahashi H, Morikawa K, Akazawa D, Murayama A, Tanaka-Kaneko K, Sata T, Tanaka Y, Mizokami M, Wakita T.  Novel Cell Culture-Adapted Genotype 2a Hepatitis C Virus Infectious Clone.   J Virol 86 (19): 10805-20 2012.10

15. Kumar V, Yi Lo PH, Sawai H, Kato N, Takahashi A, Deng Z, Urabe Y, Mbarek H, Tokunaga K, Tanaka Y, Sugiyama M, Mizokami M, Muroyama R, Tateishi R, Omata M, Koike K, Tanikawa C, Kamatani N, Kubo M, Nakamura Y, Matsuda K.  Soluble Mica and a Mica Variation as Possible Prognostic Biomarkers for Hbv-Induced Hepatocellular Carcinoma.   PLoS One 7 (9): e44743 2012.10.2

16. Nakamura M, Nishida N, Kawashima M, Aiba Y, Tanaka A, Yasunami M, Nakamura H, Komori A, Nakamuta M, Zeniya M, Hashimoto E, Ohira H, Yamamoto K, Onji M, Kaneko S, Honda M, Yamagiwa S, Nakao K, Ichida T, Takikawa H, Seike M, Umemura T, Ueno Y, Sakisaka S, Kikuchi K, Ebinuma H, Yamashiki N, Tamura S, Sugawara Y, Mori A, Yagi S, Shirabe K, Taketomi A, Arai K, Monoe K, Ichikawa T, Taniai M, Miyake Y, Kumagi T, Abe M, Yoshizawa K, Joshita S, Shimoda S, Honda K, Takahashi H, Hirano K, Takeyama Y, Harada K, Migita K, Ito M, Yatsuhashi H, Fukushima N, Ota H, Komatsu T, Saoshiro T, Ishida J, Kouno H, Yagura M, Kobayashi M, Muro T, Masaki N, Hirata K, Watanabe Y, Nakamura Y, Shimada M, Hirashima N, Komeda T, Sugi K, Koga M, Ario K, Takesaki E, Maehara Y, Uemoto S, Kokudo N, Tsubouchi H, Mizokami M, Nakanuma Y, Tokunaga K, Ishibashi H.  Genome-Wide Association Study Identifies Tnfsf15 and Pou2af1 as Susceptibility Loci for Primary Biliary Cirrhosis in the Japanese Population.   Am J Hum Genet 91 (4): 721-728 2012.10.5

17. Kawashima M, Ohashi J, Nishida N, Tokunaga K.  Evolutionary Analysis of Classical Hla Class I and Ii Genes Suggests That Recent Positive Selection Acted on Dpb1*04ratio01 in Japanese Population.   PLoS One 7 (10): e46806 2012.10.12

18. Jinam T, Nishida N, Hirai M, Kawamura S, Oota H, Umetsu K, Kimura R, Ohashi J, Tajima A, Yamamoto T, Tanabe H, Mano S, Suto Y, Kaname T, Naritomi K, Yanagi K, Niikawa N, Omoto K, Tokunaga K, Saitou N.  The History of Human Populations in the Japanese Archipelago Inferred from Genome-Wide Snp Data with a Special Reference to the Ainu and the Ryukyuan Populations.   J Hum Genet 57 (12): 787-95 2012.12


国立国際医療研究センター
肝炎・免疫研究センター
肝疾患研究部

〒272-8516 千葉県市川市国府台1-7-1
電話番号 047-372-3501/FAX 047-375-4766