研究・業績

2011年

1. Kusakabe A, Tanaka Y, Inoue M, Kurbanov F, Tatematsu K, Nojiri S, Joh T, Tsugane S, Mizokami MA Population-Based Cohort Study for the Risk Factors of Hcc among Hepatitis B Virus Mono-Infected Subjects in Japan.   J Gastroenterol 46 (1): 117-24 2011.01

2. Kusumoto S, Tanaka Y, Ueda R, Mizokami MReactivation of Hepatitis B Virus Following Rituximab-Plus-Steroid Combination Chemotherapy.   J Gastroenterol 46 (1): 9-16 2011.01

3. Sugiyama M, Tanaka Y, Nakanishi M, Mizokami MNovel Findings for the Development of Drug Therapy for Various Liver Diseases:Genetic Variation in Il-28b Is Associated with Response to the Therapy for Chronic Hepatitis C.   J Pharmacol Sci 115 (3): 263-9 2011.02

4. Kurosaki M, Tanaka Y, Nishida N, Sakamoto N, Enomoto N, Honda M, Sugiyama M, Matsuura K, Sugauchi F, Asahina Y, Nakagawa M, Watanabe M, Sakamoto M, Maekawa S, Sakai A, Kaneko S, Ito K, Masaki N, Tokunaga K, Izumi N, Mizokami MPre-Treatment Prediction of Response to Pegylated-Interferon Plus Ribavirin for Chronic Hepatitis C Using Genetic Polymorphism in Il28b and Viral Factors.   J Hepatol 54 (3): 439-48 2011.03

5. Sugauchi F, Tanaka Y, Kusumoto S, Matsuura K, Sugiyama M, Kurbanov F, Ueda R, Mizokami MVirological and Clinical Characteristics on Reactivation of Occult Hepatitis B in Patients with Hematological Malignancy.   J Med Virol 83 (3): 412-418 2011.03

6. Khan A, Tanaka Y, Kurbanov F, Elkady A, Abbas Z, Azam Z, Subhan A, Razza S, Hamid S, Jafri W, Shih J, Xia N, Takahashi K, Mishiro S, Mizokami MInvestigating an Outbreak of Acute Viral Hepatitis Caused by Hepatitis E Virus Variants in Karachi, South Pakistan.   J Med Virol 83 (4): 622-9 2011.04

7. Tatematsu K, Tanaka Y, Sugiyama M, Sudoh M, Mizokami MHost Sphingolipid Biosynthesis Is a Promising Therapeutic Target for the Inhibition of Hepatitis B Virus Replication.   J Med Virol 83 (4): 587-93 2011.04

8. Ito K, Higami K, Masaki N, Sugiyama M, Mukaide M, Saito H, Aoki Y, Sato Y, Imamura M, Murata K, Nomura H, Hige S, Adachi H, Hino K, Yatsuhashi H, Orito E, Kani S, Tanaka Y, Mizokami MThe Rs8099917 Polymorphism, When Determined by a Suitable Genotyping Method, Is a Better Predictor for Response to Pegylated Alpha Interferon/Ribavirin Therapy in Japanese Patients Than Other Single Nucleotide Polymorphisms Associated with Interleukin-28b.   J Clin Microbiol 49 (5): 1853-60 2011.05

9. Matsuura K, Tanaka Y, Kusakabe A, Hige S, Inoue J, Komatsu M, Kuramitsu T, Hirano K, Ohno T, Hasegawa I, Kobashi H, Hino K, Hiasa Y, Nomura H, Sugauchi F, Nojiri S, Joh T, Mizokami MRecommendation of Lamivudine-to-Entecavir Switching Treatment in Chronic Hepatitis B Responders: Randomized Controlled Trial.   Hepatol Res 41 (6): 505-511 2011.06

10. Tanaka Y, Kurosaki M, Nishida N, Sugiyama M, Matsuura K, Sakamoto N, Enomoto N, Yatsuhashi H, Nishiguchi S, Hino K, Hige S, Itoh Y, Tanaka E, Mochida S, Honda M, Hiasa Y, Koike A, Sugauchi F, Kaneko S, Izumi N, Tokunaga K, Mizokami MGenome-Wide Association Study Identified Itpa/Ddrgk1 Variants Reflecting Thrombocytopenia in Pegylated Interferon and Ribavirin Therapy for Chronic Hepatitis C.   Hum Mol Genet 20 (17): 3507-16 2011.09.1

11. Sugiyama M, Inui A, Shin IT, Komatsu H, Mukaide M, Masaki N, Murata K, Ito K, Nakanishi M, Fujisawa T, Mizokami MEasy-to-Use Phylogenetic Analysis System for Hepatitis B Virus Infection.   Hepatol Res 41 (10): 936-45 2011.10

12. Sugiyama M, Tanaka Y, Wakita T, Nakanishi M, Mizokami MGenetic Variation of the Il-28b Promoter Affecting Gene Expression.   PLoS One 6 (10): e26620 2011.10

共著論文

1. Kuno A, Ikehara Y, Tanaka Y, Angata T, Unno S, Sogabe M, Ozaki H, Ito K, Hirabayashi J, Mizokami M, Narimatsu H.  Multilectin Assay for Detecting Fibrosis-Specific Glyco-Alteration by Means of Lectin Microarray.   Clin Chem 57 (1): 48-56 2011.01

2. Sako A, Yasunaga H, Horiguchi H, Hashimoto H, Masaki N, Matsuda S.  Acute Hepatitis B in Japan: Incidence, Clinical Practices and Health Policy.   Hepatol Res 41 (1): 39-45 2011.01

3. Wu S, Imazeki F, Kurbanov F, Fukai K, Arai M, Kanda T, Yonemitsu Y, Tanaka Y, Mizokami M, Yokosuka O.  Evolution of Hepatitis B Genotype C Viral Quasi-Species During Hepatitis B E Antigen Seroconversion.   J Hepatol 54 (1): 19-25 2011.01

4. Yokosuka O, Kurosaki M, Imazeki F, Arase Y, Tanaka Y, Chayama K, Tanaka E, Kumada H, Izumi N, Mizokami M, Kudo M.  Management of Hepatitis B: Consensus of the Japan Society of Hepatology 2009.   Hepatol Res 41 (1): 1-21 2011.01

5. Mumtaz K, Hamid S, Ahmed S, Moatter T, Mushtaq S, Khan A, Mizokami M, Jafri W.  A Study of Genotypes, Mutants and Nucleotide Sequence of Hepatitis B Virus in Pakistan: Hbv Genotypes in Pakistan.   Hepat Mon 11 (1): 14-8 2011.01.1

6. Ishiguro S, Inoue M, Tanaka Y, Mizokami M, Iwasaki M, Tsugane S.  Impact of Viral Load of Hepatitis C on the Incidence of Hepatocellular Carcinoma: A Population-Based Cohort Study (Jphc Study).   Cancer Lett 300 (2): 173-9 2011.01.28

7. Evangelou E, Valdes AM, Kerkhof HJ, Styrkarsdottir U, Zhu Y, Meulenbelt I, Lories RJ, Karassa FB, Tylzanowski P, Bos SD, Akune T, Arden NK, Carr A, Chapman K, Cupples LA, Dai J, Deloukas P, Doherty M, Doherty S, Engstrom G, Gonzalez A, Halldorsson BV, Hammond CL, Hart DJ, Helgadottir H, Hofman A, Ikegawa S, Ingvarsson T, Jiang Q, Jonsson H, Kaprio J, Kawaguchi H, Kisand K, Kloppenburg M, Kujala UM, Lohmander LS, Loughlin J, Luyten FP, Mabuchi A, McCaskie A, Nakajima M, Nilsson PM, Nishida N, Ollier WE, Panoutsopoulou K, van de Putte T, Ralston SH, Rivadeneira F, Saarela J, Schulte-Merker S, Shi D, Slagboom PE, Sudo A, Tamm A, Tamm A, Thorleifsson G, Thorsteinsdottir U, Tsezou A, Wallis GA, Wilkinson JM, Yoshimura N, Zeggini E, Zhai G, Zhang F, Jonsdottir I, Uitterlinden AG, Felson DT, van Meurs JB, Stefansson K, Ioannidis JP, Spector TD.  Meta-Analysis of Genome-Wide Association Studies Confirms a Susceptibility Locus for Knee Osteoarthritis on Chromosome 7q22.   Ann Rheum Dis 70 (2): 349-55 2011.02

8. Gulube Z, Chirara M, Kew M, Tanaka Y, Mizokami M, Kramvis A.  Molecular Characterization of Hepatitis B Virus Isolates from Zimbabwean Blood Donors.   J Med Virol 83 (2): 235-44 2011.02

9. Kusumoto S, Tanaka Y, Mizokami M, Ueda R.  Clinical Significance of Hepatitis B Virus (Hbv)-DNA Monitoring to Detect Hbv Reactivation after Systemic Chemotherapy.   J Clin Oncol 29 (4): e100; author replye101 2011.02.1

10. Koike A, Nishida N, Yamashita D, Tokunaga K.  Comparative Analysis of Copy Number Variation Detection Methods and Database Construction.   BMC Genet 12: 29 2011.03

11. Yuen MF, Ka-Ho Wong D, Lee CK, Tanaka Y, Allain JP, Fung J, Leung J, Lin CK, Sugiyama M, Sugauchi F, Mizokami M, Lai CL.  Transmissibility of Hepatitis B Virus (Hbv) Infection through Blood Transfusion from Blood Donors with Occult Hbv Infection.   Clin Infect Dis 52 (5): 624-32 2011.03

12. Otowa T, Kawamura Y, Sugaya N, Yoshida E, Shimada T, Liu X, Tochigi M, Umekage T, Miyagawa T, Nishida N, Kaiya H, Okazaki Y, Tokunaga K, Sasaki T.  Association Study of Pde4b with Panic Disorder in the Japanese Population.   Prog Neuropsychopharmacol Biol Psychiatry 35 (2): 545-9 2011.03.30

13. Qin Y, Zhang J, Garcia T, Ito K, Gutelius D, Li J, Wands J, Tong S.  Improved Method for Rapid and Efficient Determination of Genome Replication and Protein Expression of Clinical Hepatitis B Virus Isolates.   J Clin Microbiol 49 (4): 1226-33 2011.04

14. Okamoto K, Tokunaga K, Doi K, Fujita T, Suzuki H, Katoh T, Watanabe T, Nishida N, Mabuchi A, Takahashi A, Kubo M, Maeda S, Nakamura Y, Noiri E.  Common Variation in Gpc5 Is Associated with Acquired Nephrotic Syndrome.   Nat Genet 43 (5): 459-63 2011.05

15. Sakamoto N, Nakagawa M, Tanaka Y, Sekine-Osajima Y, Ueyama M, Kurosaki M, Nishida N, Tamori A, Yuki NS, Itsui Y, Azuma S, Kakinuma S, Hige S, Itoh Y, Tanaka E, Hiasa Y, Izumi N, Tokunaga K, Mizokami M, Watanabe M.  Association of Il28b Variants with Response to Pegylated-Interferon Alpha Plus Ribavirin Combination Therapy Reveals Intersubgenotypic Differences between Genotypes 2a and 2b.   J Med Virol 83 (5): 871-878 2011.05

16. Kurotaki N, Tasaki S, Mishima H, Ono S, Imamura A, Kikuchi T, Nishida N, Tokunaga K, Yoshiura K, Ozawa H.  Identification of Novel Schizophrenia Loci by Homozygosity Mapping Using DNA Microarray Analysis.   PLoS One 6 (5): e20589 2011.06

17. Sa-Nguanmoo P, Tanaka Y, Ratanakorn P, Sugiyama M, Murakami S, Payungporn S, Sommanustweechai A, Mizokami M, Poovorawan Y.  Cross-Species Transmission of Gibbon and Orangutan Hepatitis B Virus to Upa/Scid Mice with Human Hepatocytes.   Virus Res 158 (1-2): 209-15 2011.06

18. Furusawa T, Naka I, Yamauchi T, Natsuhara K, Kimura R, Nakazawa M, Ishida T, Nishida N, Eddie R, Ohtsuka R, Ohashi J.  The Serum Leptin Level and Body Mass Index in Melanesian and Micronesian Solomon Islanders: Focus on Genetic Factors and Urbanization.   Am J Hum Biol 23 (4): 435-44 2011.07-08

19. Kurosaki M, Tanaka Y, Tanaka K, Suzuki Y, Hoshioka Y, Tamaki N, Kato T, Yasui Y, Hosokawa T, Ueda K, Tsuchiya K, Kuzuya T, Nakanishi H, Itakura J, Takahashi Y, Asahina Y, Matsuura K, Sugauchi F, Enomoto N, Nishida N, Tokunaga K, Mizokami M, Izumi N.  Relationship between Polymorphisms of the Inosine Triphosphatase Gene and Anaemia or Outcome after Treatment with Pegylated Interferon and Ribavirin.   Antivir Ther 16 (5): 685-94 2011.08

20. Yoshida H, Shiratori Y, Kudo M, Shiina S, Mizuta T, Kojiro M, Yamamoto K, Koike Y, Saito K, Koyanagi N, Kawabe T, Kawazoe S, Kobashi H, Kasugai H, Osaki Y, Araki Y, Izumi N, Oka H, Tsuji K, Toyota J, Seki T, Osawa T, Masaki N, Ichinose M, Seike M, Ishikawa A, Ueno Y, Tagawa K, Kuromatsu R, Sakisaka S, Ikeda H, Kuroda H, Kokuryu H, Yamashita T, Sakaida I, Katamoto T, Kikuchi K, Nomoto M, Omata M.  Effect of Vitamin K2 on the Recurrence of Hepatocellular Carcinoma.   Hepatology 54 (2): 532-40 2011.08

21. Naka I, Nishida N, Ohashi J.  No Evidence for Strong Recent Positive Selection Favoring the 7 Repeat Allele of Vntr in the Drd4 Gene.   PLoS One 6 (8): e24410 2011.09

22. Nakamura I, Tanaka Y, Ochiai K, Moriyasu F, Mizokami M, Imawari M.  Clarification of Interspousal Hepatitis C Virus Infection in Acute Hepatitis C Patients by Molecular Evolutionary Analyses: Consideration on Sexual and Non-Sexual Transmission between Spouses.   Hepatol Res 41 (9): 838-45 2011.09

23. Kuno A, Ikehara Y, Tanaka Y, Saito K, Ito K, Tsuruno C, Nagai S, Takahama Y, Mizokami M, Hirabayashi J, Narimatsu H.  Lect-Hepa: A Triplex Lectin-Antibody Sandwich Immunoassay for Estimating the Progression Dynamics of Liver Fibrosis Assisted by a Bedside Clinical Chemistry Analyzer and an Automated Pretreatment Machine.   Clin Chim Acta 412 (19-20): 1767-72 2011.09.18

24. Aiba Y, Nakamura M, Joshita S, Inamine T, Komori A, Yoshizawa K, Umemura T, Horie H, Migita K, Yatsuhashi H, Nakamuta M, Fukushima N, Saoshiro T, Hayashi S, Kouno H, Ota H, Muro T, Watanabe Y, Nakamura Y, Komeda T, Shimada M, Masaki N, Komatsu T, Yagura M, Sugi K, Koga M, Tsukamoto K, Tanaka E, Ishibashi H.  Genetic Polymorphisms in Ctla4 and Slc4a2 Are Differentially Associated with the Pathogenesis of Primary Biliary Cirrhosis in Japanese Patients.   J Gastroenterol 46 (10): 1203-12 2011.10

25. Suzuki H, Murata K, Gotoh T, Kusano M, Okano H, Oyamada T, Yasuda Y, Imamura M, Kudo M, Mizokami M, Sakamoto A.  Phenotype-Dependent Production of Des-Gamma-Carboxy Prothrombin in Hepatocellular Carcinoma.   J Gastroenterol 46 (10): 1219-29 2011.10

26. Furui Y, Hoshi Y, Murata K, Ito K, Suzuki K, Uchida S, Satake M, Mizokami M, Tadokoro K.  Prevalence of Amino Acid Mutation in Hepatitis C Virus Core Region among Japanese Volunteer Blood Donors.   J Med Virol 83 (11): 1924-9 2011.11

27. Wang J, Singh US, Rawal RK, Sugiyama M, Yoo J, Jha AK, Scroggin M, Huang Z, Murray MG, Govindarajan R, Tanaka Y, Korba B, Chu CK.  Antiviral Activity of Novel 2'-Fluoro-6'-Methylene-Carbocyclic Adenosine against Wild-Type and Drug-Resistant Hepatitis B Virus Mutants.   Bioorg Med Chem Lett 21 (21): 6328-31 2011.11.1

28. Kawamura Y, Otowa T, Koike A, Sugaya N, Yoshida E, Yasuda S, Inoue K, Takei K, Konishi Y, Tanii H, Shimada T, Tochigi M, Kakiuchi C, Umekage T, Liu X, Nishida N, Tokunaga K, Kuwano R, Okazaki Y, Kaiya H, Sasaki T.  A Genome-Wide Cnv Association Study on Panic Disorder in a Japanese Population.   J Hum Genet 56 (12): 852-6 2011.12

29. Miyaaki H, Ichikawa T, Yatsuhashi H, Taura N, Miuma S, Usui T, Mori S, Kamihira S, Tanaka Y, Mizokami M, Nakao K.  Suppressor of Cytokine Signal 3 and Il28 Genetic Variation Predict the Viral Response to Peginterferon and Ribavirin.   Hepatol Res 41 (12): 1216-1222 2011.12


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